Wang A, Shen J, Rodriguez AA, Saunders EJ, Chen, Janivara R, … , Lachance J, … , Kote-Jarai Z, Madduri R, Conti DV, and Haiman CA* (2023) Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nature Genetics (accepted).
Pfennig A, Petersen LN, Kachambwa P, and Lachance J* (2023) Evolutionary genetics and admixture in African populations. Genome Biology and Evolution (accepted).
Chen F, Madurri R, Rodriguez AA, … Lachance J, … Justice AC, Conti DV, and Haiman CA* (2023) Evidence of novel susceptibility variants for prostate cancer and a multiancestry polygenic risk score associated with aggressive disease in men of African ancestry. European Urology (.pdf).
Pfennig A and Lachance J* (2023) Challenges to accurately estimating sex-biased admixture from X chromosomal and autosomal ancestry proportions. American Journal of Human Genetics 110:359-367 (.pdf).
Carvalho NGR, Harris AM, and Lachance J* (2022) Different genetic architectures of complex traits and their relevance to polygenic score performance. bioRxiv (.pdf).
Dyson CJ, Pfennig A, Ariano-Sanchéz D, Lachance J, Mendelson JR, and Goodison MAD* (2022) Draft genome of the highly endangered Guatemalan Beaded Lizard, Heloderma charlesbogerti, reveals evolutionary relationships of squamates and declines in effective population sizes. G3: Genes Genomes Genetics 12(12), jkac276 (.pdf).
Kim MS, Naidoo D, Hazra U, Quiver MH, Chen WC, Simonti CN, Kachambwa P, Harlemon M, … and Lachance J* (2022) Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa. Genome Biology 12:194 (.pdf).
Chen F, Darst BF, Madurri RK, … Lachance J, … Conti DV, and Haiman CA* (2022) Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: a meta-analysis within diverse populations. eLife 11:e78304 (.pdf).
Pfennig A and Lachance J* (2022) Hybrid fitness effects modify fixation probabilities of introgressed alleles. G3: Genes Genomes Genetics 12(7), jkac113 (.pdf).
Darst BF*, Hughley R, Pfennig A, Hazra U, … Lachance J, Rebbeck TR, Conti DV, and Haiman CA* (2021) A rare germline HOXB13 variant contributes to risk of prostate cancer in men of African ancestry. European Urology 81(5): 458-462 (.pdf).
Quiver MS and Lachance J* (2021) Adaptive eQTLs reveal the evolutionary impacts of pleiotropy and tissue-specificity, while contributing to health and disease in human populations. Human Genetics and Genomics Advances 100083 (.pdf).
Hazra U and Lachance J* (2021) Polygenic adaptation is not a major driver of disparities in disease mortality across global populations. medRxiv (.pdf).
Simonti CN and Lachance J* (2021) Ancient DNA reveals that few GWAS loci have been strongly selected during recent human history. bioRxiv (.pdf)
Lachance J* (2021) Beyond stamp collecting: evolutionary and functional genomics advance our understanding of cancer biology. Cancer Research 81:1637-1638 (.pdf).
Lachance J*, Simonti CN, and Weitz JS (2020) Large sample spaces do not imply biological systems are ‘fine-tuned’. Journal of Theoretical Biology 507:110457 (.pdf).
Harlemon M, Ajayi O, Kachambwa P, Kim MS, Simonti CN, Quiver MS, … and Lachance J* (2020) A custom genotyping array reveals population-level heterogeneity in the genetic risks of prostate cancer and other cancers. Cancer Research 80:2959-2969 (.pdf).
Waldetoft KW*, Gurney J, Lachance J, Hoskisson PA, and Brown SP (2019) Evolving antibiotics against resistance: a potential platform for natural product development? mBIO 10:e02946-19 (.pdf).
Lachance J* (2019) Echoes of the neutralist-selectionist debate in an era of population genomics. Evolution 73:860-861 (.pdf).
Kim MS, Patel KP, Teng AK, Berens AJ, and Lachance J* (2018) Genetic disease risks can be misestimated across global populations. Genome Biology 19:179 (.pdf).
Hey J*, Chung Y, Sethuraraman A, Lachance J, Tishkoff SA, Sousa VC, and Wang Y (2018) Phylogeny estimation by integration over isolation with migration models. Molecular Biology and Evolution 35(11):2805–2818 (.pdf).
Andrews C, … Lachance J, … and Rebbeck TR* (2018) Development, evaluation, and implementation of a pan-African cancer research network: Men of African Descent and Carcinoma of the Prostate (MADCaP). Journal of Global Oncology Sept(4):1-14 (.pdf).
Rishishwar L, Wang L, Wang J, Yi SV, Lachance J, and Jordan IK* (2018) Evidence for positive selection on recent human transposable element insertions. Gene 675:69-75 (.pdf ).
Lachance J*, Berens AJ, Hansen MEB, Teng AK, Tishkoff SA ,and Rebbeck TR (2018) Genetic hitchhiking and population bottlenecks contribute to prostate cancer disparities in men of African descent. Cancer Research 78(9):2432-2443 (.pdf).
Berens AJ, Cooper TL, and Lachance J* (2017) The genomic health of ancient hominins. Human Biology 89:7-19 (.pdf).
Pagani L, Lawson D, Jagoda E, Mörseburg A, Eriksson A, … Lachance J, … and Metspalu M* (2016) Genomic analyses inform on migration events during the peopling of Eurasia. Nature 538:238-242 (.pdf ).
Hsieh PH, Woerner AE, Wall JD, Lachance J, Tishkoff SA, Gutenkunst RN, and Hammer MF* (2016) Model-based analyses of whole genome data reveal a complex evolutionary history involving archaic introgression in Central African Pygmies. Genome Research 26:279-290 (.pdf).
Hsieh PH, Veeramah K, Lachance J, Tishkoff SA, Wall JD, Hammer MF, and Gutenkunst RN* (2016) Whole genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection. Genome Research 26:291-300 (.pdf).
Lachance J* (2016) Hardy-Weinberg proportions and the mathematical population genetics of randomly mating populations. Encyclopedia of Evolutionary Biology, edited by Kliman RM. Academic Press. Vol. 2, pp. 208-211 (.pdf).
Karmin M, Saag L, Vicente M, Wilson Sayres MA, … Lachance J (author 33 of 100), … and Kivisild T* (2015) A recent bottleneck of Y chromosome diversity coincides with a global change in culture. Genome Research 25:459-466 (.pdf).
Lachance J* and Tishkoff SA* (2014) Biased gene conversion skews allele frequencies in human populations, increasing the disease burden of recessive alleles. American Journal of Human Genetics 95:408-420 (.pdf).
Lachance J* and Tishkoff SA* (2013) Population genomics of human adaptation. Annual Review of Ecology, Evolution, and Systematics 44:123-143 (.pdf).
Wang S, Lachance J, Tishkoff SA, Hey J, and Xing J* (2013) Apparent variation in Neanderthal admixture among African populations is consistent with gene flow from non-African populations. Genome Biology and Evolution 5:2075-2081 (.pdf).
Lachance J*, Jung L, and True JR (2013) Genetic background and GxE interactions modulate the penetrance of a naturally occurring wing defect in Drosophila melanogaster. G3: Genes Genomes Genetics 3:1893-1901 (.pdf).
Lachance J* and Tishkoff SA* (2013) SNP ascertainment bias in population genetic analyses: Why it is important, and how to correct it. BioEssays 35:780-786 (.pdf).
Johnson NA* and Lachance J (2012) The genetics of sex chromosomes: evolution and implications for hybrid incompatibility. Annals of the New York Academy of Natural Sciences: The Year in Evolutionary Biology 1256:E1-E22 (.pdf).
Lachance J, Vernot B, Elbers CC, Ferwerda B, Froment A, Bodo JM, Lema G, Fu W, Nyambo TB, Rebbeck TR, Zhang K, Akey JM, and Tishkoff SA* (2012) Evolutionary history and adaptation from high coverage whole-genome sequences of diverse African hunter-gatherers. Cell 150:457-46 (.pdf) .
Pickrell J*, Patterson N, Carbieri C, Berthold F, Gerlach L, Güldemann T, Kure B, Mpoloka SW, Nakagawa H, Nauman C, Lipson M, Loh PR, Lachance J, Mountain J, Bustamante C, Berger B, Tishkoff SA, Henn B, Stoneking M, Reich D*, and Pakendorf B* (2012) The genetic prehistory of southern Africa. Nature Communications doi:10.1038/ncomms2140 (.pdf).
Lachance J*, Johnson NA, and True JR (2011) The population genetics of X-autosome synthetic lethals and steriles. Genetics 189:1011-1027 (.pdf).
Lachance J* (2010) Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations. BMC Medical Genomics 3:57 (.pdf).
Lachance J* and True JR* (2010) X-autosome incompatibilities in Drosophila melanogaster: Tests of Haldane’s rule and geographic patterns within species. Evolution 64:3035-3046 (.pdf).
Lachance J* (2009) Inbreeding, pedigree size, and the most recent common ancestor of humanity. Journal of Theoretical Biology 261:238-247 (.pdf).
Lachance J* (2009) Detecting selection-induced departures from Hardy-Weinberg proportions. Genetics Selection Evolution 41:15 (.pdf).
Lachance J* (2008) A fundamental relationship between genotype frequencies and fitnesses. Genetics 180:1087-93 (.pdf).
Yukilevich R*, Lachance J, Aoki F, and True JR (2008) Long-term adaptation of epistatic genetic networks. Evolution 62:2215-2235 (.pdf).
Lachance J* (2008) Subject to Change. Nature 454:916 (.pdf).